LUPISIT GM 2/1000 Tablet 10's

LUPISIT GM 2/1000 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride,  Metformin and Sitagliptin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin.

Before taking LUPISIT GM 2/1000 TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding before taking the medicine. LUPISIT GM 2/1000 TABLET is not suitable for use by children and adolescents under 18 years of age.

Avoid consumption of alcohol during management with LUPISIT GM 2/1000 TABLET as it may increase or decrease the blood sugar lowering action of LUPISIT GM 2/1000 TABLET and increases the risk of lactic acidosis. The most common side effects of taking LUPISIT GM 2/1000 TABLET are taste disturbance, nausea, diarrhea, stomachache, and vomiting. Contact your doctor if any of the above symptoms worsen.

USES OF LUPISIT GM 2/1000 TABLET

• It is used to manage type 2 diabetes mellitus

HOW LUPISIT GM 2/1000 TABLET WORKS

LUPISIT GM 2/1000 TABLET is a combination of Glimepiride, Metformin, and Sitagliptin. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing the intestinal absorption of glucose, and in muscles by increasing insulin sensitivity and improving peripheral glucose uptake and utilization. Glimepiride blocks the ATP-sensitive potassium channel by binding non-specifically to the B sites of both sulfonylurea receptor-1 (SUR1) and sulfonylurea receptor-2A (SUR2A) subunits as well as the A site of SUR1 subunit of the channel to promote insulin secretion from the beta cell. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar when there is too much sugar in the blood.

DIRECTIONS FOR USE

Take LUPISIT GM 2/1000 TABLET as advised by your physician. Swallow LUPISIT GM 2/1000 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking LUPISIT GM 2/1000 TABLET without informing your doctor.

SIDE EFFECTS OF LUPISIT GM 2/1000 TABLET

COMMON

• nausea
• diarrhea
• abdominal pain
• hypoglycaemia
• taste change
• flatulence
• stomach pain
• headache
• skin rash
• upper respiratory tract infection

Stop taking LUPISIT GM 2/1000 TABLET and consult your doctor immediately if you experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels including loss of consciousness, seizures